Remeron for Sleep: Benefits, Side Effects and Uses

Remeron for Sleep Benefits, Side Effects and Uses

Remeron or Mirtazapine  is a useful agent for depression, anemia and sleep. It has many other uses and is a very versatile drug. It can help with OCD or PTSD. These are some major depressive disorders it can help to control the symptoms of. It is said that Mirtazapine was introduced into the United States in 1996. It was mainly prescribed for major depression and now it has evolved to be use for many more applications. It is often the first-line of defense against depression and it is prescribed for those who have a sexual dysfunction in relationship to depression. It is also prescribed for sleep issues related to depression.

Remeron does have some side effects but supposedly they they have lighter side effects than other antidepressants. This drug is fast acting as it usually affects depression within in the first week of consumption. They act faster than depressants in the SSRI class. It may not be a well-known anti-depressant but it is very effective. It seems to be safe and effective for long-term use, and is comparable in effectiveness to drugs such as amitriptyline, clomipramine, doxepin, fluoxetine, paroxetine, citalopram, and venlafaxine with a better side effect profile.       

1. Depression Reliever

It is recorded in eight controlled major depression trials that Mirtazapine (as mentioned before) started working within one week and was more effective than placebo. Mirtazapine had an efficacy profile(Medicine. … Specifically, efficacy, refers to “whether a drug demonstrates a health benefit over a placebo or other intervention when tested in an ideal situation, such as a tightly controlled clinical trial.“) that was shown to surpass multiple SSRIs and SNRIs, in earlier weeks of therapy. The drug is equivalent in efficacy to tricyclic antidepressants, with a better tolerability profile. The drug was also as effective as trazodone in short-term periods for mild to severe depressions this includes elderly patients who had anxiety or sleep disturbances. It was very effective for depression and it worked better than amitriptyline, fluoxetine, paroxetine, and citalopram. Compared to SSRI class drugs patients who used remeron had a 74 percent greater chance of remission from depression in the first two weeks of using remeron.    

Remeron reduces Depression by:

  • Blocking α2-adrenoceptors, which lead to enhanced release of norepinephrine and serotonin.
  • Potent blocking of serotonin 5-HT2 and 5-HT3, which increases stimulation of the 5-HT1 receptor.
  • Blocking the histamine H1 receptors, causing a sedative effect, and improvement of sleep.
  • Activating mu- and kappa 3-opioid receptors, which reduces pain.
  • Decreasing glutamate in rats.


2. Remeron an Enemy of Panic Disorder and Anxiety

Remeron an Enemy of Panic Disorder and Anxiety

Remeron isn’t considered the first-line of defense for treating anxiety. Despite this fact it has been effective in treating the root causes of anxiety and its symptom. So, why it is not a first-line of defense is somewhat of a mystery. Impressively, in a study conducted on 44 patients who had general anxiety disorder with symptoms manifesting on average for 12.3 years. A respectable 79.5 percent had a positive response and 44 percent had a full recovery from the anxiety.

People addicted to benzodiazepines (any of a class of heterocyclic organic compounds used as tranquilizers, such as Librium and Valium.) were able to stop using them once they started taking remeron.


Remeron Helping Anxiety Cases:

  • Mirtazapine reduced pre-surgery anxiety and insomnia more than placebo and comparatively to diazepam. Very good results people facing the uncertainty of surgery
  • Mirtazapine reduced anxiety, sleeping difficulties, and nausea caused by chemotherapy  very promising for cancer patients
  • Mirtazapine helped 7 out of 10 people with major depression, who also suffered from generalized anxiety disorder and panic disorder (small, open-label pilot study). A solid 70 percent success rate very effective.
  • Mirtazapine reduced the intensity of panic attacks in patients with panic disorder, showing effectiveness comparable to fluoxetine. Another winning benefit of remeron.
  • Three out of six patients with severe, chronic PTSD benefited from mirtazapine.
  • Social anxiety was reduced in 5 out of 12 patients. Almost 50 percent the effectiveness here needs to be improved.


Mirtazapine’s Anti-Anxiety Mechanisms:

  • Blocks 5-HT2a and 5-HT3 receptors.
  • Significantly increased GABA and decreased glutamate (nucleus accumbens, rats).


3. Remeron Memory and Information Enhancer

In studies conducted with rats Remeron had notable effects on memory improving activities and in some cases improved memory retention. Remember, this was conducted on rats not humans. The potential for human memory expansion and improving memory activities is not known. The effects seen in rats may be promising for human candidates. This may not be a proven fact but remeron may help patients with depression retain positive information. Generally, patients suffering from depression tend to retain negative information about themselves.


4. Remeron Kills Chronic Pain

Remeron Kills Chronic Pain

Antidepressants have been used for non-traditional uses such as being administered to patients with chronic pain. Which seems strange because generally they are use to treat depression not chronic pain. Here again, remeron has been effective in treating chronic pain. A patient’s chronic back pain did not respond to the drug amitriptyline but responded to mirtazapine treatment. Mirtazapine activates the k-opioid receptors, which may be a large contributor to the pain relieving effects which is very encouraging for chronic pain sufferers.     


5. Remeron more Effective in Treating Post Traumatic Syndrome Disorder than Placebo

Remeron more Effective in Treating Post Traumatic Syndrome Disorder than Placebo

It has been shown that remeron is more effective in treating certain measures of PTSD than placebo. The same study also discovered that remeron helped to improve general anxiety disorder symptoms. After four weeks, three out of six patients reported a very noticeable reduction in the severity of PTSD symptoms.


6. It is Victorious over Obsessive-Compulsive Disorder       

There have been smaller studies conducted using remeron on OCD patients and the effects have been promising and the study concluded remeron could be an effective treatment for OCD. In 49 patients, mirtazapine in combination with citalopram resulted in “much improved” or “very much improved” ratings around the fourth week, compared to the citalopram and placebo group that did not see noticeable results until about the eighth week. The citalopram and placebo took twice as long as the remeron to work.


7. Remeron reduces the Intensity and Frequency Of Migraines

Remeron reduces the Intensity and Frequency Of Migraines

Mirtazapine is believed to prevent migraines through histamine and 5-HT2 receptors, and is thought to treat migraines through the 5-HT1 receptor. Further investigation is suggested to prove if it will work to eliminate migraines or not.


Itching Inhibitor

There is speculation that remeron may stop itching. This speculation has not been proven through clinical study but it is believed that the medicine may bind binding of skin and/or brain serotonin and histamine receptors.

If remeron is as effective as studies show in helping patients battling with depression and anxiety disorders this is welcome news for those patients. Depression can leave a person feeling mentally and emotionally paralyzed. They don’t feel like in participating in life. It leaves them full of apathy and negative thoughts. Depression if left unchecked could lead to suicidal thoughts ultimately causing a person to commit suicide in very extreme cases. This drug could potentially save lives and steer people on the road to recovery. The goal of this drug is to help people to completely recover from depression. Another benefit of the drug as mentioned earlier is that it will start working within a week.


Insomnia Buster

Another welcome benefit of remeron is that it can help alleviate the effects of insomnia. Like antihistamines this drug blocks histamine H1 receptor which has a major sedating effect on the brain and the body and helps people with insomnia fall into a peaceful sleep.

Mirtazapine increases deep sleep (SWS), sleep onset, and sleep continuity. Mirtazapine was shown to decrease cortisol and ghrelin throughout the night, while leptin and melatonin increased but remeron was shown to have a slightly effect in reducing REM. Tricyclic antidepressants, MAOIs, and SSRIs all have the ability to strongly suppress REM sleep which means remeron is lacking in this area compared to these other drugs.


Remeron Deletes Low Appetite/Anorexia Nervosa caused by depression.

What this means is that people who have tendencies to be depressed will tend to stop eating. They will have a negative mindset and look at themselves in the mirror with jaded perceptions. They will think they are too fat force themselves to stop eating to get to the “perfect” weight. This throws their mind into a vicious cycle because they will never get to the “perfect” weight. This drug can stop that destructive cycle of thinking.

Patients who take remeron report they eat more and gain more weight. This will be healthy in some cases in other cases this could be dangerous. The drug has an appetite stimulating mechanism. So, eating more and gaining weight are two side effects of the drug.The appetite-stimulating effects of mirtazapine and antidepressant effects of the medication show it could be promising drug in use of patients that have developed anorexia caused by depression, or de depression caused by anorexia. This is very promising news for people who battle with depression and anorexia.  


Factors for Remeron-Induced Weight Gain  

Factors for Remeron-Induced Weight Gain

  • Blocking 5HT2C and H1 receptors.
  • Mirtazapine possibly reduces the energy your body expends, which results in weight gain


Warnings for Using Remeron

Don’t take this drug if you are allergic to it or if you are currently taking tryptophan (sometimes called L-tryptophan). Don’t use remeron if you have used a MAO inhibitor within the last 14 days. A dangerous drug interaction will occur within the body it could be fatal. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.


Medical Conditions to Report to your Doctor before Using Remeron:

Call your doctor at once if you have

  • liver or kidney disease;
  • narrow-angle glaucoma;
  • bipolar disorder (manic depression);
  • seizures or epilepsy;
  • low blood pressure or dizzy spells;
  • high cholesterol or triglycerides;
  • heart disease, including angina (chest pain);
  • a history of heart attack or stroke; or
  • a history of drug abuse or suicidal thoughts.

Some young people have suicidal thoughts when first taking antidepressants.So, if you have a young one at home taking remeron make sure the doctor is regularly monitoring their mental and emotional progress while taking remeron. Your family and caregiver must be alerted to any changes in mood or symptoms. For instance, is their depression growing worse or are they more aggressive and anxious.


More Warnings:

It is not known whether mirtazapine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. The risks for the unborn child just are not known at this time. It is suggested that pregnant women do not take remeron while pregnant.

It is yet to be determined whether mirtazapine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. It is recommended women breast-feeding do not take remeron. There could be risk for the feeding baby.

The Remeron SolTab orally disintegrating tablet may contain phenylalanine. Talk to your doctor before using this form of mirtazapine if you have phenylketonuria (PKU). (an inherited inability to metabolize phenylalanine that causes brain and nerve damage if untreated.) This could cause extensive nerve and brain damage if this condition is left unchecked. Check with your doctor if you having any inkling you may have phenylketonuria.


Instructions for Taking Remeron:

  • Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Follow your doctor’s orders if they are different than prescription label instructions
  • Remeron is usually taken once a day at bedtime. Follow your doctor’s instructions.
  • Take the regular Remeron tablet with water.
  • To take the Remeron SolTab orally disintegrating tablet:
  • Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
  • Use dry hands to remove the tablet and place it in your mouth.
  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.

It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment. Normally changes in behavior have occurred after the first week of taking remeron.

Do not stop using Remeron suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using mirtazapine. Ask the doctor for a reasonable schedule to get off the medication.

Store at room temperature away from moisture, heat, and light. Like any other medication.


Side Effects of Remeron:

  • Get emergency medical help if you have any signs of an allergic reaction to Remeron: skin rash or hives; difficult breathing; swelling of your face, lips, tongue, or throat. Major allergic alerts
  • Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. The drug is supposed to relieve these symptoms not increase them. If these signs increased you have a major problem with your body reacting to this drug.


Call your doctor at once if you have:

  • Racing thoughts like you have taken a stimulant, decreased need for sleep, unusual risk-taking behavior or boldness, feelings of extreme happiness or sadness like at bipolar levels, being more talkative than usual incessant chattering is more like it;
  • Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • A light-headed feeling, like you might pass out like you are walking on air;
  • Changes in weight or appetite; these may not be a harmful side effects as many patients have reported these side effects occurring after using remeron
  • Sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; feeling like you developed the flu instantaneously Rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet uncommon patterns of pain in these areas;
  • High levels of serotonin in the body – agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; these will be signs of serotonin overdose
  • Low levels of sodium in the body – headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or dehydration traits
  • Severe nervous system reaction – very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.The nervous system is just a step out of functioning normally. Or it could be way off center


Common Remeron side effects include:

  • drowsiness, dizziness; reality around you has a spinning effect
  • strange dreams; especially if you never dream
  • vision changes; double vision, rainbow colors around images, blurriness
  • dry mouth; your mouth feels like a desert
  • Constipation;
  • Increased appetite; This may be normal or
  • Weight gain. This may be normal

Warning: this is not an inexhaustive list of side effects this drug may cause. Also tell your doctor if you are taking other medications because combining them with remeron may cause enhanced sleepiness if the other drugs make you sleepy in the first place. These include sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell the doctor about all medications you are using or will stop or start using while consuming remeron especially the following drugs:

  • cimetidine (Tagamet);
  • diazepam (Valium);
  • ketoconazole;
  • St. John’s wort;
  • tramadol;
  • tryptophan (sometimes called L-tryptophan);
  • medicine to treat mood disorders, thought disorders, or mental illness – such as lithium, other antidepressants, or antipsychotics;
  • migraine headache medicine – sumatriptan, zolmitriptan, and others; or
  • seizure medicine – carbamazepine, phenytoin.



We have learned some of the benefits, uses and serious side effects of using remeron. The title detailed that the article was to be about the side effects, uses and benefits of using the drug for sleep disorders. But upon researching the subject it was found there was a lot more information as to the benefits, uses and side effects of remeron. Be careful whenever using an antidepressant it could have effects on the body that could be dangerous even fatal. Always consult your doctor before taking any antidepressants.

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