Meet the Latest Craze in Nootropics, Noopept!

Noopept is one of the most popular Nootropics available today. It’s cheap, safe and effective.

 

What Is Noopept?

Noopept is a “smart drug” that has very similar effects to the racetam class of nootropics and is considered to be one of the strongest and most effective nootropics currently available. This supplement hasn’t yet been approved by the FDA and isn’t available for sale in traditional brick and mortar health food outlets.

In Russia where the drug was developed it is currently used to treat age-related cognitive decline. Elsewhere it is used as a nootropic to enhance learning abilities and focus.

Noopept, a synthetic nootropic, is the brand name of N-phenylacetyl-L-prolylglycine ethyl ester. This water soluble proline-containing dipeptide was originally designed as an analog of the very popular nootropic, Piracetam, and is often claimed to be 1000 times stronger.

Dipeptides (two amino acids joined together by a peptide bond) are molecules small enough to be readily absorbed into the bloodstream. In this case the amino acids are Glycine and Proline. Once Noopept is absorbed it is broken down by the body into usable components. Its main metabolite is Cycloprolylglycine, and this is thought to be responsible for the enhanced effects that Noopept offers.

Various animal studies have shown that Noopept can be neuroprotective and memory-enhancing. Research into its effects on humans is limited and its reported benefits are based on anecdotal accounts.

Noopept stimulates the release of Brain-Derived Neurotrophic Factor (BDNF) which strengthens the growth of new neurons and synapses. It also stimulates the AMPA and NMDA receptors and pathways which play roles in memory creation and thought processes.

In this Noopept review we’ll look at its benefits, side effects, and proper dosage levels, as well as outlining some popular Noopept stacks that you can create for additional or improved benefits. Suggested vendors and approximate prices are also covered.

 

Noopept Benefits

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Why You Need To Know What Racetam Is

What Is A Racetam?

Racetams are a well regarded class of nootropic cognitive enhancing drugs that are known for improving learning, memory and focus, and for enhancing mood and energy levels as well as positively affecting brain health.

The oldest racetam, developed in 1964 is Piracetam and there are 19 racetams in all, although not all are available as supplements. The full list of racetams is as follows:

Aniracetam – Brivaracetam – Coluracetam – Dimiracetam – Etiracetam – Fasoracetam – Imuracetam – Levetiracetam – Nebracetam – Nefiracetam – Nicoracetam – Oxiracetam – Phenylpiracetam – Piracetam – Pramiracetam – Rolipram – Rolziracetam – and Seletracetam.

Not all of these are nootropics, with some being only used in a limited medical capacity. In this article we’ll look at those nootropics currently available so that you can get a better idea of their suitability for your needs.

 

Terms That You Should know

Neurotransmitter – these are chemical messengers that facilitate communications across the brain.

Acetylcholine – this is a neurotransmitter within the brain that plays an essential role in numerous levels of cognitive functionality. It is known to be particularly important for the memory formation process.

 

Racetam Benefits And Uses

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Centrophenoxine Reviewed in Detail

Centrophenoxine, also known as meclofenoxate, is a nootropic supplement that has previously been sold as a prescription drug under the brand name Lucidril. It is thought to be able to help protect the brain against aging, age related side effects and from damage caused by environmental toxins, and is widely used for this purpose.

As a cholinergic, Centrophenoxine is a frequently stacked with other nootropics such as Racetams and Noopept.

There are many cognitive benefits related to this well known nootropic. In this Centrophenoxine review we’ll learn what it is, how it works, what benefits to expect, and what side effects you might experience. Then you can decide if Centrophenoxine is the right nootropic for you.

Some definitions that will help you better understand this article if you’re new to nootropics.

Neurotransmitter – chemical messengers that facilitate communicate across the brain.

Acetylcholine – is a neurotransmitter within the brain that carries out an essential role in multiple levels of cognitive functionality, and is known to be particularly important for the memory formation process. It affects the autonomic nervous system, the peripheral nervous system, the central nervous system, and the somatic nervous system.  By elevating acetylcholine levels, doctors have been able to slow degeneration and treat conditions like Alzheimer’s.

Choline –  is the basic form of acetylcholine, and our bodies transform choline into acetylcholine.

Choline is found in a lot of the foods that we consume. Eggs and shrimp are both high in choline, and other dietary sources include, liver, beef, cauliflower, tofu, almonds, and peanut butter. The recommended daily intake of choline for adults is in the region of 425-550 mg per day, and it is estimated that as much as 90% of the population have a choline-deficient diet. Unless you’re eating at least 5 eggs each day or consuming large amounts of other choline rich foods, your brain may not be getting the choline it needs to stay healthy and productive. Without choline, your brain can’t create the acetylcholine it needs. Low choline levels are often linked to headaches.

Cholinergic – a substance that delivers or enhances the action of choline. The brain’s cholinergic system produces the neurotransmitter acetylcholine.

Dimethylaminoethanol – DMAE is a substance that occurs naturally in foods and is also synthesized in the brain. As a supplement It has been marketed for its claimed benefits relating to cognitive enhancement, anti-aging, and skin rejuvenation. The structure of DMAE is similar to that of choline but there is a large debate as to the ability of DMAE to act as precursor to acetylcholine like choline. The reason for this debate is that it is thought that once DMAE crosses the blood brain barrier, it is impossible to convert into choline. The presence of DMAE in the brain cell membrane provides increased protection against free radical damage.

Antioxidant –  molecules that prevent the oxidation of other molecules. Oxidation is a chemical reaction that can produce free radicals, leading to chain reactions that damage cells.

 

What is Centrophenoxine?

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The Complete Guide to Zembrin

Zembrin is marketed as mood enhancing herbal supplement that combats stress, reduces anxiety and eases tension. It’s also reported to sharpen focus, increase clarity, boost motivation and improve concentration.

Those are impressive claims, and a supplement that can deliver all of those benefits sounds like the perfect antidote to the stresses and complications of 21st century life.

In this Zembrin review I’m going to dig into those claims and attempt to give you the full picture surrounding Zembrin so that you can make an informed choice when deciding if this is the right supplement for your needs.

 

What Is Zembrin?

Zembrin is a botanical supplement that has been studied for safety and effectiveness in both clinical and preclinical trials and has a long history of use with the San and Khoikhoi peoples of South Africa who use the source of Zembrin – Sceletium tortuosum –  to boost mood and ease fatigue, stress, and anxiety.

Zembrin is a patented, standardized extract of the South African Namaqualand plant, Sceletium tortuosum. Sceletium tortuosum is a succulent plant that grows in arid regions.

This herb known by San Bushmen as “kanna,” and “channa,” and by Dutch settlers as “kougoed,” has been used by the San people of South Africa for its mood altering properties since prehistoric times. Sceletium tortuosum was used and traded by San hunter-gatherers and pastoralists for medicinal, social and spiritual purposes. Colonial Dutch settlers also made use of the plant’s benefits.

While Sceletium tortuosum is known as a psychoactive herb, it isn’t known to be a hallucinogenic and is traditionally used to increase endurance, elevate mood, impart clarity of thinking, enhance decision making  and reduce the effects of hunger, thirst and stress. Kanna is taken prior to stressful events such as hunting for its mind focusing effects and endurance enhancing effects.

While kanna is not a thirst-suppressant or hunger-suppressant, it is considered invaluable to help deal with the stress that arises from being thirsty or hungry when walking long distances in the wilderness.

sceletium-tortuosum-is-a-flowering-succulent-herb-whose-traditional-preparation-involves-crushing-all-parts-of-the-plants

Image copyright Dr Nigel Gericke

Sceletium tortuosum is a flowering succulent herb whose traditional preparation involves crushing all parts of the plants – leaves, stems, flowers and sometimes roots – and fermenting this material for up to a week. The fermented material is then dried in the sun. An alternative method omits the fermentation step. To gain the benefits of the herb, the dried material is chewed and the plants indigenous name “Kanna” means something to chew. Alternatively, the plant can be picked and dried without the fermentation step. The Sceletium tortuosum extract used in supplements is produced in a similar way, with the aerial parts of the plant being used.  

Today, through a formal benefit-sharing agreement with the South African San Council, the developers of Zembrin, HG&H Pharmaceuticals, protect the interests of the San people who originally discovered this plant’s benefits. Because of this, Zembrin is the only Sceletium product to carry the logo of the South African San Council.

The Sceletium plant grows in the wild in South Africa, but is now a protected endangered species, so all of the plant materials used to produce Zembrin are cultivated on a commercial scale by the manufacturer. The controlled growing environment of this Sceletium tortuosum also allows the consistency of the source materials to be maintained.

With over ten years of research and development Zembrin is the only Sceletium extract to have the benefit of scientifically backed evidence for its claimed effects.

Lower doses of the Sceletium tortuosum extract are available without prescription, but the developers are hoping to produce a higher dose product as a botanical medicine for clinical use in the treatment of mental health diseases.

Pharmaceutical companies have shown considerable interest in this plant extract, and research grants have been provided by global leaders including Astrazeneca, Eli-Lilly, GlaxoSmithKline, Johnson & Johnson, Pfizer, Roche, and Wyeth.

The United States Federal Drug Administration (FDA) has recently approved the first-ever orally ingested botanical medicine, so the precedent has been set for exciting new treatments using ancient medicinal plant extracts like Zembrin in the future.  

After an independent review of the preclinical and clinical studies by a panel of leading experts in the USA, Zembrin was formally designated as Generally Regarded As Safe (GRAS), in January 2011.

The safety and quality of Zembrin is assured, and it is manufactured to meet the highest international standards, being produced at a certified EU-GMP (European Union Good Manufacturing Practice) facility.

Zembrin is a 2:1 concentration of Sceletium based on dry weight and is equivalent to 16-50mg of the dry weight of the plant itself.

Zembrin

  • has been given Generally Recognized As Safe (GRAS) status in USA.
  • has been clinically studied for efficacy.
  • has been studied for safety in pre-clinical and clinical studies.
  • is the only Sceletium extract with published pharmacology.
  • is manufactured at a certified EU-GMP manufacturer.
  • is the first standardized extract to be made from Sceletium.
  • is produced from a sustainable cultivated chemotype of Sceletium.
  • is the only Sceletium product to carry the logo of the South African San Council.

 

Zembrin Benefits And Supporting Scientific Research

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All You Need to Know About Sensoril

Sensoril is a patented form of concentrated Ashwagandha (Withania somnifera) extract. Ashwagandha is an ancient and well known herb, used extensively in Ayurvedic and alternative medicine. It’s a powerful Adaptogen which helps to induce calm and helps the body to tolerate stress.

In this Sensoril review we’ll learn more about Ashwagandha benefits and discover if Sensoril is better than the traditional form of the herb.

 

What Is Sensoril?

The manufactures of Sensoril claim that their product is 8 times more powerful than standard Ashwagandha.

Ashwagandha is a traditional herbal medicine used for over 3000 years to reduce stress and  fatigue, correct a lack of energy, improve concentration, reduce anxiety and enhance mood. It’s commonly known as Indian Ginseng and Winter Cherry. Ashwagandha isn’t related to ginseng, but it has similar benefits, hence the name. It is used in Ayurveda in a similar way to the Panax ginseng in Traditional Chinese Medicine although it is considered to be less stimulating.

When taken daily as a tonic it has shown the ability to reduce stress and support better mood, and treat conditions including fatigue, muscle pain, cognitive dysfunction, inflammation and cardiovascular system issues.

Sensoril is produced from both the roots and leaves of the Ashwagandha shrub which is part of the Solanaceae family. Other Solanaceae members include tomatoes, peppers and potatoes.

The herb is native to arid regions of India, northern Africa, and the Middle East, and is also cultivated in the United States.

Over 200 studies have been carried out on the healing benefits of this botanical. Ashwagandha has demonstrated an ability to:

  • Protect the immune system
  • Combat the effects of stress
  • Improve learning, memory, and reaction time
  • Reduce anxiety and depression without causing side effects.
  • Help to reduce brain-cell degeneration
  • Stabilize blood sugar
  • Lower cholesterol
  • Reduce inflammation
  • Increase libido

As an Adaptogenic herb, the effects of Ashwagandha increase over time and improve your response to environmental stresses as well as internal stress, including sleep difficulties and anxiety.

The Latin meaning of the species name somnifera, actually means sleep-inducing.

Sensoril was developed by a company called NutraGenesis who offer branded, proprietary, clinically tested nutraceutical ingredients used in food, beverages and dietary supplements.

Sensoril offers the most potent Ashwagandha bioactives currently available, standardized to a minimum of 10% glycowithanolides. This has been shown to decrease cortisol in the body and at the same time enhance the overall mood of the user.

Sensoril’s proven structure and function claims have been submitted to the Food and Drug Administration.

How Does Ashwagandha Work?
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