Meet the Latest Craze in Nootropics, Noopept!


Noopept is one of the most popular Nootropics available today. It’s cheap, safe and effective.

What Is Noopept?

Noopept is a “smart drug” that has very similar effects to the racetam class of nootropics and is considered to be one of the strongest and most effective nootropics currently available. This supplement hasn’t yet been approved by the FDA and isn’t available for sale in traditional brick and mortar health food outlets.

In Russia where the drug was developed it is currently used to treat age-related cognitive decline. Elsewhere it is used as a nootropic to enhance learning abilities and focus.

Noopept, a synthetic nootropic, is the brand name of N-phenylacetyl-L-prolylglycine ethyl ester. This water soluble proline-containing dipeptide was originally designed as an analog of the very popular nootropic, Piracetam, and is often claimed to be 1000 times stronger.

Dipeptides (two amino acids joined together by a peptide bond) are molecules small enough to be readily absorbed into the bloodstream. In this case the amino acids are Glycine and Proline. Once Noopept is absorbed it is broken down by the body into usable components. Its main metabolite is Cycloprolylglycine, and this is thought to be responsible for the enhanced effects that Noopept offers.

Various animal studies have shown that Noopept can be neuroprotective and memory-enhancing. Research into its effects on humans is limited and its reported benefits are based on anecdotal accounts.

Noopept stimulates the release of Brain-Derived Neurotrophic Factor (BDNF) which strengthens the growth of new neurons and synapses. It also stimulates the AMPA and NMDA receptors and pathways which play roles in memory creation and thought processes.

In this Noopept review we’ll look at its benefits, side effects, and proper dosage levels, as well as outlining some popular Noopept stacks that you can create for additional or improved benefits. Suggested vendors and approximate prices are also covered.


Noopept Benefits

Noopept has been found to improve memory, focus, learning capacity, and concentration. Its effects are similar to those delivered by Piracetam and include:

Less brain fog: Noopept helps you to assemble your thoughts more quickly and makes it possible to articulate them more effectively. You’re less likely to lose your train of thought or forget a piece of information that you were exposed to only a few minutes earlier.

Better vocabulary: Noopept lets you pluck words from your wider vocabulary when you need them. The words need to be there in the first place though. Noopept won’t make you an eloquent orator all by itself, but it will let you rapidly choose more precise and expressive words from the vocabulary that you already possess.

Increased motivation: This is a hugely beneficial effect of Noopept for most people. Unlike Piracetam which can make you feel anxious to get tasks completed, Noopept gives you certainty that you will get them done. It provides a calm, focused energy that lets you stick with and complete even the most boring and mentally draining tasks.

Improved mental clarity: With Noopept your mind is more active, making you more aware of your surroundings. This improved clarity lets you absorb more detail, no matter where you are or what you’re doing. Some people have even claimed to experience enhanced peripheral vision, but this isn’t an effect reported consistently, so your mileage may vary.

Better spatial processing: Spatial memory is a cognitive process that you use all of the time. It allows you to know how to get from one place to another without giving it much thought. Like when you drive home from work pretty much on autopilot. Spatial memory is also used to look at an area and decide how things will best fit into the space – like packing the trunk of your car.

Better spatial processing is useful for everyone, but is particularly helpful for those whose work involves physics, mathematics and chemistry.


Strengthens long term memory: Long term memory is dependant on protein synthesis, which is crucial for the synaptic plasticity of the human brain. Protein synthesis allows for structural change in neurons. In a similar way that structural changes in muscles occur when mTOR (mammalian target of rapamycin) is activated, which causes muscle cells to increase protein synthesis, Noopept increases Brain-derived neurotrophic factor (BDNF) which has been investigated for its potential as a protein synthesis product.

Prevents blurring of memories:  Noopept is able to sensitize acetylcholine receptors. The more  acetylcholine activity, the better new memories are able to formed without old memories being recalled at the same time and the two possibly getting merged. Noopept can help to deliver clear, accurate, undistorted memories.

Possible anti-anxiety effects: Some trials have found that Noopept has the ability to lower some anxiety markers, but the mechanism for this effect isn’t yet understood. As a general benefit for people without clinical anxiety this effect is useful to ‘take the edge off’, but if you suffer with anxiety or a related disorder, Noopept is unlikely to be able to have any significant benefit in this regard.

Better overall brain communication: Strengthened connections and the growth of new synapses linking the left and right hemispheres of the brain are enhanced while taking Noopept.

Improved mood: Noopept has shown the ability to stimulate certain Serotonin receptors, which may lead to positive effects on mood for some people.


What Does Noopept Feel Like?

Some users report experiencing a mild euphoria when they take Noopept. This euphoria isn’t “euphoric” in the sense of feeling an overwhelming  rush of energy, it’s more a sensation of being alert and open, calm, confident and content.

It has also been described as having effects that are comparable to a low dose of ecstasy (if you are at all familiar with that). Anxiety is reduced, especially social anxiety which makes socializing more pleasurable, and sensory detail is much more pronounced.

People also report feelings of greater self esteem when they take this supplement and this is accompanied by an ease of communication generated by that boost.

Completion of daily tasks is easier and more enjoyable when taking Noopept.


What Is the Dosage For Noopept?

The right Noopept dosage is typically considered to be around 10 – 30 milligrams a day. To establish the right dose for your needs you should take your bodyweight into account.

If you weigh under 140 pounds (63 kg), then it is recommended that you take 10 mg per day.

Those weighing between 140 – 200 pounds (63 kg – 90 kg) can try a 20 milligram daily dose.

At weights over 200 pounds, a daily dose of 30 milligrams may be required.

You should always begin with the lowest dose and evaluate the effects. A low dose may be perfectly acceptable for you.

Divide your dose throughout the day to keep Noopept active in your system as the drug has a very short half life.

Noopept is non toxic, and is considered to be a very safe nootropic to take when you stick to the recommended daily doses of 10 – 30 milligrams.

If you purchase Noopept in powder form, you must weigh the powder on an accurate digital scale. When you’re dealing in such small doses, the difference between 30 mg and 100 mg won’t be discernable with the human eye.

When to take Noopept – Noopept can be taken with or without food, at any time of the day. Food (or the lack of) does not seem to have an impact on the absorption of the substance.


Noopept Side Effects

Clinical trials conducted by the manufacturers of Noopept have demonstrated the safety of the substance. These studies have shown it to be effective and to have low toxicity at the recommended dosages.

One study showed that 20 mg of Noopept generated 1.8 times fewer side effects than 1200 mg of Piracetam.

There is a small amount of data however which suggests that dangerous overdoses can occur. So it is very important to stay within the dosage guidelines. Noopept is a very powerful compound and should be taken responsibly. The likelihood of overdose is higher than with nootropics in the racetam family.

Small overdose will generally lead to unpleasant side effects like headaches, irritability and blunting of emotions. Larger overdoses could be much worse!

Some of the common side effects of Noopept that are common at higher dosages are:

  • Headache
  • Insomnia
  • Fatigue
  • Nausea
  • Gastrointestinal Problems

If you are taking any medications, it would be advisable to discuss Noopept with your doctor before you start taking it.

Currently there are no records of dangerous drug interactions but this doesn’t mean that they cannot occur.

Noopept is reported to increase the effects of alcohol. Noopept increases blood flow to the brain, which will result in more alcohol in the brain and more intense effects from alcohol.

Some users report that they build a tolerance to Noopept’s effects when taking it every day over an extended period of time. To rectify this, cycle Noopept, taking a break from it for a couple of weeks if you notice its effects decreasing. Once you begin to take Noopept again, you should find that its effects are noticeable once more, if not, then a longer break is needed.

Some sources recommend taking Noopept for no longer than 56 days before taking a break.

An indirect side effect of Noopept is its effect on your attitude toward other people. Because you could be full of energy and enthusiasm and bursting with knowledge, while others not taking Noopept will be less energized, you may find that you experience irritability and annoyance with them. Watch out for that negativity and try to catch yourself to stop this possible side effect from affecting your relationships.



Where To Buy Noopept

Noopept is available from Internet vendors including Nootropics Depot, Pure Nootropics,, New Star Nootropics and New Mind. All of these retailers are currently recommended by the nootropics community on Reddit as trustworthy suppliers of genuine, high quality, nootropic supplements.

Because Noopept is effective in very small doses it costs a lot less than other nootropics, even the common racetams.

Nootropics Depot offers Noopept powder in 5 gram and 10 gram sizes starting at $8. Given that one gram will provide 100 ten mg doses, it’s easy to see how affordable this supplement is.

For convenience and to avoid needing to measure powder on scales, you can purchase Noopept as capsules. At Nootropics Depot 30 mg capsules start at $10 for 30.

Pure Nootropics offers powder in 15 gram and 30 gram sizes, starting at $19.  Ninety capsules with a 20 mg dose cost $20. And a more readily absorbed 10 mg sublingual solution containing 70 doses retails for $27.

Powders can be taken mixed with a glass of water or packed into your own capsules with an encapsulator once measured. Sublingual drops should be placed under the tongue.


Noopept Stacks

The practise of stacking supplements was developed by athletes who attempted to obtain extra benefits by combining substances to create powerful synergistic effects. Stacking is used in the same way when it comes to nootropic drugs. Taking multiple supplements at the same time can lead to additional advantages and the intensification of certain effects.

Before you stack any nootropics you should familiarize yourself with the various individual supplements. It’s not a good idea to take a general description from the internet and take it for granted that you will experience the same effects. Your own experience could be less pronounced or much stronger.

Only by learning how each nootropic effects you can you design a stack that will give you the effects that you are hoping to achieve.

When you create a stack, you are in effect conducting an experiment on yourself and on your brain in particular.

Use low doses to begin with, take notes, give things time to work and then make adjustments. The worst thing that you can do when designing your stack is to rush.

During important events like college exams, work presentations and development of important projects it’s not advisable to experiment with a new stack – you could end up with results that are detrimental to your performance.

From current information it appears that Noopept is generally safe to stack with other nootropics. There are some reports of adverse drug interactions, so it’s your responsibility to look into the possible effects that combining substances can cause, taking into account any medications that you may be taking.

Some common Noopept stacks that you may be interested in are outlined below.


Noopept Stack For Better Memory And Cognition – Choline & Noopept

Choline is considered a nootropic nutrient. By taking large amounts of choline by itself many people experience a nootropic effect. Choline doses between 500 mg to 1000 mg seem to be the most beneficial.

Noopept actually makes the brain more responsive to choline, and combining the two substances creates a really powerful synergy that boosts cognitive performance and enhances memory.

Choline is found in many foods and is a very safe supplement. This stack (theoretically) shouldn’t lead to any adverse effects, and user reviews for this combination have been positive.


Noopept Stack For Cognitive Boost –  Piracetam,  Noopept And Choline

Piracetam and Noopept work in different ways. Piracetam affects acetylcholine in the brain, while Noopept affects glutamate. By combining the two supplements it is thought that they can enhance the effects of each other. Adding a choline source like Alpha GPC or Citicoline meets the brain’s need for increased acetylcholine and can prevent the headaches often associated with Piracetam use.

For users, this stack offers improvements in thought processes, idea generation, memory retention and recall, and the ability to perform calculations.


Noopept Stack For Increased Sociability And Focus –  Phenibut and Noopept

The Noopept Phenibut stack is an effective stack for improving sociability, mood and focus. Noopept provides enhanced memory, cognition and alertness, while Phenibut contributes a calming substance that decreases anxiety and increases sociability. Together they render a calm stimulant effect, combined with focus and clarity.

When you first use this stack start with lower than normal doses of both substances and make sure that you familiarize yourself on how to use Phenibut properly.


Noopept Stack for Relaxed Focus – L-theanine And Noopept

L-theanine is a calming amino acid that provides stimulant effects. Extracted from green tea, L-theanine’s stimulant effects are greater than those generated by Phenibut and it is good for creating a relaxed, calm yet alert mood without drowsiness.

Using Noopept with L-theanine would be quite similar to the Noopept Phenibut stack. Some people report that Noopept is a strong stimulant and that combining it with L- theanine’s relaxing and calming effect helps to take the edge off a strong Noopept dose.



Noopept is a strong nootropic on its own and can be stacked with other substances to enhance its effects. Taking Noopept can improve brain function, generate better overall cognitive performance,  enhance memory, increase learning ability, improve logical thinking and spatial processing, generate calm energy, improve mood with a reduction in anxiety, increase perception and create a sense of clarity and focus.

Noopept increases your brain’s response to the natural nootropic choline and is reported to have fewer side effects than Piracetam.

Because the dose needed to generate beneficial effects is so small, Noopept is a very affordable nootropic to take on a regular basis.

Noopept makes a good starting point for beginners to nootropics. It’s inexpensive, the dosage is very small, and it is reported to have a high success rate.

Start with 10 mg a day and see how it works for you.

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