How to Build the Perfect Nootropic Stack

How to build the perfect nootropic stack

Here we are talking about brain power food again. This time the question is how do you assemble the best nootropic stack? Is there such a thing as the perfect nootropic stack? What would make one better than another? How would you create a nootropic stack? Nootropic stack is defined as “A nootropic stack, simply put, is the combination of two or more supplements that have beneficial effects on memory, learning, focus, or motivation, in order to create a synergistic effect in the brain greater than any increase in cognition than the supplements you “stack” could create on their own.” In other words you will take the best nootropic compounds and consume them collectively instead of taking them one after the other indiviually in a stack.

History of Nootropic Stack

According to this article the nootropic phenom started way back in the 1960’s with the first drug being introduced was to neutralize “motion sickness”. Fast forward to the 1970’s and the first nootropic drug for memory was introduced. A Romanian doctor named Dr. Corneliu Giurgea, combined  use a Greek combination of “nous” meaning “mind” and “trepein” meaning “to bend”. Literally, the drugs were able to help bend the mind. Currently nootropics have became much safer to use and go beyond just enhancing memory. Just a few short years ago it was “taboo” to take these brain enhancers without a prescription now everyone finds it thrilling to take the drugs without a prescription and to actually get involved in the industry.  


Nootropic Stacks

It can be difficult to choose what to include in the ideal nootropic stack. There are so many stacks for different purposes. You want to choose the stack that will have the best effects for your mind. Whether you want a stack to help you focus, improve memory or  reduce anxiety. Nootropic supplements individually can benefit the the mind but if you combine them into a stack they they are supposed to have a synergistic effect on your mind. As the above definition suggests they will have a much better effect on the mind than any one supplement would individually have on the mind. This is why people consume stacks instead of the supplements individually because it will boost the functioning of their brains many times more than just one supplement could.


Preformulated stacks    

This is one option for selecting a stack. You could buy a prepackaged stack from a supplement manufacturer. They would put the supplements together in a ready made package for you to purchase. They will come in capsule form. These “off-the-shelf” options are guaranteed to work to a certain extent and they will already be put together for you. The downside of this choice is that you cannot control the dosages you intake and you will not be able to control the intensity of the effects of the stack. If this is important to you there will be no time spent measuring out how much supplement or which supplement you want to combine to your customized stack.

If you choose to go with this option then make sure you buy your stack from a reputable supplement company. Mind Lab Pro is a reputable supplement company you can buy your preformulated stacks from and here are 11 of their nootropic stacks:




Brain Activities Cognizin stimulates

Brain Activities Pterostilbene stimulates

Cognizin can stimulate brain cells which maximize neural electrical impulses that are the starting points for all thought. So, it helps you think more clearly. This supplement also helps to synthesize phosphatidylcholine (PC), the major phospholipid found in brain cell membranes. Combining brain power and phospholipid synthesis, cognizin may be uniquely qualified to take the task of intensive brain cell regeneration and repair. There is no definite clinical evidence to support this hypothesis. It also supports neurotransmitters including, acetylcholine, while supplying brain-protective antioxidant activity.     


Potential Nootropic Effects of Cognizin

Powerfully empowers cognitive powers without the standard crash like stimulants. Cognizin has been shown in human research to promote mood balance, memory, attention, focus and concentration. In the long run it will help maintain healthy brain function against age-related structural changes and mental decline. MLP’S cognizin has been supported by many human clinical trials the company claims.


Sharp PS Green


Brain Activities Sharp PS Green Activates

This nootropic stack is said to contain 15% of the brains fat content in its ingredients. It concentrates in brain cell membranes, where where it helps maintain fluidity, optimizes receptors, and promotes neurotransmitters like acetylcholine and dopamine. It supports brain cell energy production by increasing glucose metabolism. It could increase nerve growth factor support brain cell creation, maintenance and repair. No clinical support for this claim. Ps also helps neighboring immune cells dispose of damaged toxin brain cells protecting nearby brain cells from collateral damage.


Potential Nootropic Benefits

PS sharpen memory, slow cognitive decline, and promote a positive-minded outlook. It has potential to help elderly with brain deterioration apparently slowing the progression of memory loss while helping with mood, anxiety, socialization and mental clarity. As a result, PS is the only nootropic with an FDA-qualified claim for reducing cognitive decline risk. As a result, PS is the only nootropic with an FDA-qualified claim for reducing cognitive decline risk.


Bacopa monnieri

Bacopa’s active bacosides are antioxidants that improve other brain antioxidants including superoxide dismutase (SOD) and glutathione peroxidase (GPx). This synergistic antioxidant activity helps buffer brain cells from the age-accelerating effects of free radicals. It also promotes acetylcholine, GABA & serotonin – all brain chemicals tied to focused thinking, clear memory and healthy mood. Animal (not human) research claims it may boost cerebral blood flow by 25%.


Potential Nootropic effects of Bacopa monnieri

It may have strong ties to memory retention and a long relationship with new learning and retention. It may also slow the rate of forgetting newly acquired knowledge. Scientists claim that it may accelerate mental processing, optimize cognition under stress, and promote relaxation.


Promising Cognitive Results Bacopa Monnieri

Bacopa monnieri

Bacopa Form

  • Dried Bacopa plant extract (1.05 g/ day for 3 months)
  • Fresh whole Bacopa plant extract (100 mg / day for 3 months)
  • Bacopa monnieri dosed at 300 mg
  • Bacopa monnieri dosed at 300 mg


Study Subjects & Design

  • School children (n=40) (age: 6-8 y), single blind trial (related to Dried Bacopa plant extract (1.05 g/ day for 3 months)
  • Children with ADHD (n=36) , Randomized, double blinded, placebo controlled  (related to Fresh whole Bacopa plant extract (100 mg / day for 3 months)
  • Adults (n=76) (age:40-65 y) , single blind trial (related to Bacopa monnieri dosed at 300 mg
  • Adults, Double-blinded, placebo controlled (related to Bacopa monnieri dosed at 300 mg)


Researchers’ Observations

  • Significant improvement in maze learning, immediate memory, perception & reaction/performance times (related to School children (n=40) (age: 6-8 y), single blind trial)
  • Significant improvement in learning and memory tasks (related to Children with ADHD (n=36) , Randomized, double blinded, placebo controlled)  
  • Significant improvement in learning, task assessing attention, verbal and visual short-term memory and the retrieval of pre-experimental knowledge (related to Adults (n=76) (age:40-65 y) , single blind trial)
  • Improved early information processing, verbal learning and memory consolidation  (related to Adults, Double-blinded, placebo controlled)


Lion’s Mane Mushroom


Brain Activities Lion’s Mane Mushroom activates

This is the only mushroom that supports brain health. , Lion’s Mane supplies active nootropics called hericenones and erinacines. Animal research (not human research) Animal research suggests Lion’s Mane stimulates Nerve Growth Factor (NGF) production, which accelerates neural regeneration and myelin nerve sheath synthesis. Maximized Nerve Growth Factor could support brain plasticity for new learning and memory storage. As well as promoting robust brain cell replication and healthy brain cell membrane function.


Potential Nootropic Effects

A double-blind, placebo-controlled trial associated Lion’s mane Mushroom to extensive cognitive function improvements in adults aged 50-80 with mild cognitive impairment. Clinical trial researchers have also suggested that Lion’s Mane may help to maintain mood balance.




Brain Activities Pterostilbene stimulates

Pterostilbene which is a high bio-availability polyphenol found in grape and blueberries it has soothing anti-oxidant properties. These properties help to keep the brain healthy in the aging process. In vitro research shows cells exposed to pterostilbene exhibit increased expression of antioxidant enzymes including glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR). Pterostilbene’s unique brain-supportive activity optimizes cognition, modulates brain cell stress, and helps protect cerebral blood vessels.


Potential Nootropic Benefits    

Pterostilbene is valued as a neuroprotective nootropic for overall healthy brain function and brain aging. Its performance-oriented nootropic activity is based on early animal research (not human research) and it may help with human mood and cognition.




Brain Activities Tyrosine Activates

Brain Activities Tyrosine Activates

Tyrosine is an amino acid compound used to synthesize catecholamine neurotransmitters involved in memory, mood and mental processing, including dopamine, epinephrine, and norepinephrine. Here we go again with animal studies. Animal studies (not human studies) suggest that may counter the impact of brain stress in animal brains not human brains. Restoring neurotransmitters that are depleted by stress to promote peak cognitive function in animal brains and whether this translates to potential the same potential impact in human brains is not yet known.


Potential Nootropic Effects

Human research has suggested that tyrosine may to promote working memory under multitasking circumstances and maximize mental performance under high stress, fatigue and sleep deprivation. In addition to its well-known reputation as a nootropic for maintaining mental performance under stress, Tyrosine has recently drawn interest as an attention and focus-oriented nootropic.




L-Theanine activates these brain activities

L-Theanine activates these brain activities

L-theanine helps to increase the activity of alpha brainwaves which are related to a state of of wakeful relaxation and enhanced creativity. It calms down excitable neurotransmitters and activates calming neurotransmitters such as serotonin, dopamine and GABA. Scientists suggest that L-theanine can control the brain’s “attention circuitry” which really means it can help yhr brain concentrate and focus on tasks more efficiently. It may also protect neurons from damage, potentially helping to maintain clear thinking during the aging process.


Potential Nootropic Effects  

L-theanine may activate a calm, relaxed sense of tranquility while simultaneously sharpening attention, focus and alertness. It is used for studying, new learning, creative problem solving, art, or other tasks that require the brain to be in a quiet, contemplative state. It also acts like a stimulant as mentioned before. Ironically, L-theanine cancels out the harsh “jittery” effects of caffeine. It acts as a calming stimulant which is paradoxical to say the least.


L-theanine’s Promising Nootropic Effects Concluded from Human Studies


L-Theanine Dose

  • L-Theanine 50 mg, L-Theanine 200 mg
  • L-Theanine 200 mg
  • L-Theanine 50 mg
  • L-Theanine 250 mg


Subjects & Design

  • 8 Female university students) (age: 18-22 y), placebo-controlled, three-way crossover trial (related to L-Theanine 50 mg, L-Theanine 200 mg)
  • 20 healthy males (age range 18–30 y), placebo controlled (related to L-Theanine 200 mg)
  • 35 healthy young participants, randomized, placebo-controlled (related to L-Theanine 50 mg
  • 15 participants (mean age 27.8 y), placebo-controlled (related to L-Theanine 250 mg)


Researchers’ Observations

  • Reported dose-dependent increase in alpha activity in occipital and parietal brain areas 30 min after consumption of L-theanine compared with placebo. (related to 8 Female university students) (age: 18-22 y), placebo-controlled, three-way crossover trial )
  • L-theanine increased alpha brain wave activity in the occipital area, compared with placebo, among those with higher reported anxiety (p<0.05) (related to 20 healthy males (age range 18–30 y), placebo controlled)
  • Compared with placebo on EEG at 45, 60, 75, 90, and 105 min after ingestion, L-theanine 50 mg produced greater and increasing alpha activity (p<0.05) (related to 35 healthy young participants, randomized, placebo-controlled)
  • Attention-related alpha activity was greater and background alpha reduced for the L-theanine condition compared with placebo (significant attention modulation index, (p<0.05) (related to 15 participants (mean age 27.8 y), placebo-controlled)


Rhodiola rosea


Brain Activities Rhodiola Rosea Stimulates

Rhodiola may stimulate and maintain sustain cognition-critical neurotransmitters including norepinephrine, dopamine, and serotonin. It may further help these neurotransmitters by helping their transfer across the brain blood barrier. This may speed up their effects in the brain. It also contains acetylcholine-protective and antioxidant properties that may assist  with the decline caused by age.

In small doses it may increase the brain’s bioelectrical activity. Research suggests Rhodiola’s effects will activate within 30 minutes of intake and last up to six hours.


Potential Nootropic Effects

As an “adaptogen” herb it can buffer physical and mental stress while supporting brain energy, promoting clear, calm thinking under taxing conditions. Rhodiola is used to enhance mental processing, memory, learning, attention span, mood and work capacity. It also claimed fame as a mind-body performance-enhancer among Eastern Bloc era Olympic biathletes and powerlifters. So it is reported.




Brain activities stimulated by vinpocetine

Brain Activities Lion’s Mane Mushroom activates

Vinpocetine is lab synthesized from the periwinkle plant and it  enhances blood flow to the brain, which promotes glucose and oxygen utilization for brain energy metabolism.  These brain activities could help enhance blood flow to the brain. This in turn promotes glucose and oxygen utilization for brain energy metabolism. This also helps to carry oxygen to all parts of the brain. This could also help to maintain neurons that may otherwise be lost to  weak cerebral blood flow. Vinpocetine supplies antioxidant activity which  protects the brain from oxidative stress and toxins. It also supports  brain chemicals serotonin, dopamine and norepinephrine.


Potential Nootropic Benefits

Vinpocetine has rapid transport to the brain. This could mean that its effects on the brain may be felt immediately. It promotes attention, concentration, and memory in the short term (showing benefit to memory within 2 days). The long-term effects are it helps with inhibiting age-related brain deterioration and helps to improve cognitive functions.         


Vitamin B6


Brain Activities vitamin B6 stimulates

B6 maximizes neurotransmitters, helping synthesize serotonin, norepinephrine and GABA while supporting Tryptophan-serotonin, 5-HTP- serotonin, and DOPA-dopamine conversions. B6 also protects the blood brain barrier’s microvascular system from the homocysteine that can damage blood vessel linings and help to produce cognitive decline. In other words it protects against brain damage. B6 supports in the formation of myelin, the the fatty sheath that surrounds and protects neurons.


B6 Potential Nootropic Effects

Mild B6 deficiency is common which may cause loss of neurotransmitters to the point the brain could lose cognitive abilities. This is just a mild B6 deficiency. What would a major B6 deficiency cause? B6 supplementation will restore the neurotransmitter balance which will make for healthy brain chemical production and conversion, and has been related in clinical studies to cognitive  performance, mood balancing and a slight increase in the brain’s ability to store information.


Final Thoughts

Potential Nootropic Benefits

Here has been listed several preformulated nootropic stacks manufactured by a reputable supplement company. This is a good base to build a nootropic stack from. The supplements are already combined and the doses determined for you. You can take one or a combination of these nootropic stacks. You will not have to add and figure out the individual doses of each supplement. It has already been done for you but if you choose to you can combine your own nootropic stacks from scratch. If you choose this option you can control which individual supplement and what dose of that supplement will go into your customized stack.

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