DL-Phenylalanine (DLPA) Uses, Benefits, and Side Effects

Nootropics are often referred to as ‘smart drugs,’ because they can enhance cognitive function. They can boost focus, learning capacity, memory, mood, motivation, and energy.

The term “nootropic” was first used in 1972 by a pharmacologist, who took the name from 2 Greek words “noos” meaning ‘the mind’, and “tropein”, meaning towards. The literal translation of the name is ‘to turn towards the mind’.

The drugs have a wide range of benefits and are widely used by people who work in demanding professions and need to keep a competitive edge, and students who are studying for exams.

Modern life is so busy and demanding, that many people are turning to nootropics to stretch their limits and capabilities.

 

What qualities does a nootropic have?

To be classed as a nootropic, a drug must have the following qualities:

It should improve learning capacity and memory

It should have few or no adverse side effects

It should have no detectable toxicity in the human body

It should increase the brain’s resistance to physical and chemical injuries

 

How do nootropics work?

The different types of nootropics differ from each other in their chemical structure and in how they work, as they are both extracts of herbs and plants, as well as synthetic compounds. They also affect different parts of the brain and so they produce different effects because of this. Experts are always looking to tap into the full potential of the human brain, and with people living longer, there is a lot of research going into developing drugs that can protect the brain from degenerative damage. Cognitive problems are usually associated with a deficiency of one or more of the brain chemicals called neurotransmitters.
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Best Focus Pills You Can Legally Buy over the Counter

The ability to concentrate is essential for the successful completion of any task, but staying focused can sometimes be a challenge due to distractions, mental or physical fatigue, anxiety, and lack of sleep. If you find that you often have trouble concentrating, nootropics might just be the answer you’re looking for.

By affecting the production and balance of chemicals in our brain called neurotransmitters, nootropics increase the brain’s capacity to concentrate, learn and focus.

 

What are nootropics?

Often when drugs are developed to treat certain health conditions, researchers discover that they have other properties that make them well-suited for other purposes too and the drug can be used ‘off label’ for other reasons.

Nootropics are drugs that were originally developed to treat conditions like ADHD and narcolepsy, but their properties mean that they make ideal ‘smart drugs’, which are used to boost focus, concentration, and learning capacity.

When taken as a supplement, nootropics can enhance cognitive ability. They are known to boost memory and concentration, and so they are popular among students when they are studying for exams, and even when they want to boost their energy for partying.  

Some other drugs that have similar effects can cause negative side effects if they are used for a long period of time or if they are abused, but generally, nootropics are safe, they can have a protective effect on the brain, and there are little or no side effects associated with use.

Many nootropics work in a similar way to each other. They increase the communication between neurons in the brain, promote healthy brain cells, and balance the levels of neurotransmitters, the chemical messengers in the brain. Neurotransmitters control mood, focus, concentration, and energy so it is important that they are working as well as they should in the brain.

 

All about nootropics    

All about nootropics

The first ever nootropic, Piracetam, was invented in 1963 by Belgian pharmacologists. They found that the active compound boosted cognitive ability but was it not toxic and did not produce side effects, unlike other brain stimulants.

Piracetam is one of the best-known nootropics and is part of the Racetam family along with Aniracetam, Phenylpiracetam, Pramiracetam, Oxiracetam, Nefiracetam, Coluracetam and Nebracetam. These are all synthetic compounds made in a lab, but there are also several effective herbal and natural nootropic supplements available.

 

How do nootropics work?

Nootropics work by increasing the levels and signalling ability of the neurotransmitters in the brain. Neurotransmitters are chemical messengers in the brain, and when they can send their signals more efficiently, overall concentration is better, mood is better, and the user has a better attention span, and more capacity for mental work. Eventually, nootropics cause an improvement to the health and functioning of your brain as well.

Some nootropics are vasodilators, which means they increase the blood flow to your brain. This supplies the brain with more oxygen, nutrients, and glucose, which it needs when you need to focus for long periods.

The brain requires a large amount of energy to function at its best, to sustain consciousness and to remain focused. It uses 20% of your energy expenditure, despite making up only 5% of your total body weight.

When you are performing mental work, and having to stay focused and alert, this uses up a lot of energy. By improving brain circulation, and the flow of oxygen to the brain, you will notice that your memory and focus is better, and that you are able to sustain concentration for longer periods.

Some natural nootropics supply the brain cells with energy, and they are popular, as they act on the brain immediately. These include L-Carnitine, Caffeine, Creatine, and Ginkgo Biloba. These can create feelings of being jittery however, unlike nootropics.

Nootropics can also help to protect the brain against the effects of age-related degeneration. They can stimulate the growth of new neurons, which could prevent disorders like Alzheimer’s disease from developing. This is big news at a time when people are living longer than ever and scientists are trying to halt the rise in neurodegenerative diseases.

 

What are nootropics prescribed for?

 

ADHD

ADHD (Attention deficit hyperactivity disorder)

ADHD (Attention deficit hyperactivity disorder) is a condition which presents with behavioural symptoms such as the inability to pay attention and focus, hyperactivity, and impulsivity.

The condition is usually diagnosed in childhood, and symptoms tend to become more noticeable when a child has to interact with others under different circumstances and in different settings, such as when they start school. Most cases of ADHD are diagnosed in children between 6 and 12 years old. Symptoms can become less pronounced as people get older, though adults can continue to experience problems like anxiety and sleep disorders. Adults are not generally diagnosed with ADHD, and if they are, it is likely they have had it since childhood and it has been misdiagnosed as something else. Unfortunately, ADHD is often misdiagnosed.
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L-Tyrosine: Benefits, Side Effects, Uses and Doses

How can amino acids not be healthy for you? They are supposed to be the building blocks of life. Can there really be any side effects to amino acids? L-Tyrosine or 4-hydroxyphenylalanine is one of the twenty standard amino acids that cells use to synthesize proteins. It is a non-essential amino acid with a polar side group. Its codons are UAC and UAU. Tyrosine comes from the greek word tyros meaning cheese. It is not clear how cheese plays into the function of an amino acid. This particular amino acid was discovered by Justus von Liebig, a German chemist, in the protein casein in cheese. This is how the greek word for cheese ties in. Tyrosine is a hydrophilic amino acid and is much more soluble in water than its precursor, phenylalanine, due to the thermodynamic favorability of the hydrogen bonding between the hydroxyl group of one molecule of tyrosine and the carboxyl group of another.

 

The many names of Tyrosine:

Insufficient Evidence for the Following Uses

2-Acetylamino-3-(4-Hydroxyphenyl)-Propanoic Acid, Acetyl-L-Tyrosine, Acétyl-L-Tyrosine, L-Tyrosine, N-Acetyl L-Tyrosine, N-Acetyl-L-Tyrosine, N-Acétyl L-Tyrosine, N-Acetyl-Tyrosine, N-Acétyl-Tyrosine, Tyrosine, Tyr, Tyrosinum, 2-amino-3-(4-hydroxyphenyl)propionic acid.           

 

Tyrosine Origins

Tyrosine can also be found in dairy products, meats, fish, eggs, nuts, beans, oats, and wheat. Tyrosine is produced from another amino acid. Tyrosine is used in protein supplements to treat an inherited disorder called phenylketonuria (PKU). People who have this disorder cannot produce phenylalanine properly so their bodies cannot produce tyrosine. So, to meet their needs they take extra tyrosine supplements. People take tyrosine supplements for the following issues depression, attention deficit disorder (ADD), attention deficit-hyperactivity disorder (ADHD), the inability to stay awake (narcolepsy), and improving alertness following sleep deprivation. It is also used for stress, premenstrual syndrome (PMS), Parkinson’s disease, Alzheimer’s disease, chronic fatigue syndrome (CFS), alcohol and cocaine withdrawal, heart disease and stroke, ED (erectile dysfunction), loss of interest in sex, schizophrenia, and as a suntan agent and appetite suppressant. There are many various reasons why people will take tyrosine. Tyrosine is even applied topically to skin to reduce age-related wrinkles.

 

How it works

The body uses tyrosine to make chemical messengers that are involved in conditions involving the brain such as mental alertness and many other cognitive functions.

 

Uses of L-Tyrosine

Uses of L-Tyrosine

Back to the inherited disorder phenylketonuria people who have this have low levels of tyrosine and they are advised to take 6 grams of tyrosine per 100 grams of protein to improve tyrosine levels in the body. Supposedly if you take tyrosine two hours before a test it will help improve memory in healthy people. It will also improve memory, mood and it does not improve mood or speed of reaction to visual or noise stimuli in healthy people.  This is not a proven fact though. Studies have verified that tyrosine does improve memory under stressful conditions as as cold-stress or multitasking.

It will improve mental alertness after loss of sleep. In lines with this Taking 150 mg/kg of tyrosine after someone has lost a night of sleep will help them stay awake three hours longer than they would have otherwise.

Attention Deficit Disorder (ADD) Supposedly taking tyrosine by mouth does not help adults with ADD. Furthermore, Attention deficit-hyperactivity disorder (ADHD). Taking tyrosine by mouth does not seem to help childhood ADHD. Tyrosine taken by mouth is ineffective in treating just mild depression. It don’t even crack major depressive disorders.

Tyrosine fails in exercise performance as well. Taking tyrosine before walking on a treadmill with a load carriage doesn’t help strength or endurance. Also, taking tyrosine, alone or with polydextrose 70, does not seem to improve heart rate or performance during a cycling test. In the above uses tyrosine seems pretty ineffective.
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L-Dopa Benefits, Uses, Side Effects and Dosages

You know that L-Dopa sounds like an illegal drug. It sounds like an illegal version of marijuana. So what type of benefits and uses could this drug offer. Definitely there are side effects to this chemical. It is said that beans are a good source of L-Dopa. If this is an illegal substance what could it benefit or what could it be used for.

 

What is L-Dopa

L-Dopa or levodopa is an amino acid that is manufactured and used as a normal biology of humans, animals, and some plants. Some animals and humans make it via biosynthesis from the amino acid L-tyrosine. L-Dopa is a precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) collectively known as catecholamines. (any of a class of aromatic amines that includes a number of neurotransmitters such as epinephrine and dopamine.) It also mediates neurotrophic factor  by the brain and CNS. L-Dopa is a man-made drug as well being sold as a psychoactive drug with the INN levodopa; trade names include Sinemet, Pharmacopeia, Atamet, Stalevo, Madopar, and Prolopa. So the drug is manufactured naturally by the body and commercially by man. Which version is more powerful or damaging? As a clinical drug it  is used to treat Parkinson’s disease and dopamine-responsive dystonia. As a nootropic it is used to treat depression and anxiety. So it serves  a dual purpose as a clinical and a psychological drug.  

 

L-Dopa Benefits:

Some benefits are it treats parkinson’s disease and dopamine-responsive dystonia ( Segawa Syndrome (SS) also known as Dopamine-responsive dystonia (DRD), Segawa’s disease, Segawa’s dystonia and hereditary progressive dystonia with diurnal fluctuation, is a genetic movement disorder which usually manifests itself during early childhood at around ages 5–8 years. It has a variable start age). It doesn’t cure these conditions but makes them tolerable to exist with. It can also help to cure depression and anxiety.

As was noted before it is a precursor to neurotransmitters especially dopamine. Dopamine cannot cross the brain blood barrier so it must be synthesized in the brain. But L-Dopa can cross the brain blood barrier which lead to increased levels of the pleasure hormone dopamine. Once L-Dopa crossed the brain blood barrier it is converted into dopamine by the DOPA decarboxylase enzyme which also goes by the name aromatic L-amino acid decarboxylase. Part of this process to happen is that Vitamin B6 (Pyridoxal phosphate) must be a part of this synthesizing process. In the artificial realm vitamin B6 are stacked with L-Dopa supplements for a more efficient conversion process to dopamine.

The process is finalized L-Doa will also have a stimulatory effect on the Central Nervous System. The hypothalamus area of the brain along with the pituitary gland release increased levels of the growth hormone (HGH). This indicates another indirect benefit of L-Dopa that it helps the human body to grow. It may increased the levels and activities of the adrenergic hormones Norepinephrine and Epinephrine. The combined presence of these increased quantities of these hormones and neurotransmitters are responsible for many benefits including regulating motor control, sex drive, immune function, fat loss (and gain), lean muscle growth, bone density, energy levels, and even sleep cycles.

L-Dopa can help with the aging process because it is taken for anti-aging and life extension purposes. It is reported as a human ages they lose about 40,000 dopamine neurons in the brain. L-Dopa supplements replenish the dopamine neurons that are supposedly lost. Unfortunately when 70% of your brain dopamine neurons are depleted parkinson’s disease will develop. L-Dopa can replenish the dopamine neurons depleted and may be able to stop parkinson’s disease from developing. It has been theorized that if a human lives long enough they could lose 100% of the dopamine neurons which would theoretically guarantee that parkinson’s disease would develop. But there is no clinical evidence to support this theory.
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IDRA-21 Benefits, Uses and Side Effects

Nootropics are often referred to as ‘smart drugs,’ because they have the ability to enhance cognitive function. They can boost focus, learning capacity, memory, mood, motivation, and energy.

The word “nootropic” was first used in 1972 by a pharmacologist, who took the name from 2 Greek words “noos” meaning ‘the mind’, and “tropein”, meaning towards. The literal translation of the name is ‘to turn towards the mind’.

The drugs have a wide range of benefits and are widely used by people who work in demanding professions and need to keep a competitive edge, and students who are studying for exams.

Modern life is often relentless, so people are turning to nootropics to take them past what they previously considered to be their limits.

 

What qualities does a nootropic have?

To be classed as a nootropic, a drug must have these qualities:

It should improve learning and memory

It should have few or no adverse side effects

It should have no detectable toxicity

It should increase the brain’s resistance to physical and chemical injuries

 

How do nootropics work?

The different nootropics available differ from each other in their chemical structure and in how they work, as they are both extracts of herbs and plants, as well as synthetic compounds. They also affect different parts of the brain and so they produce different effects. Experts are always looking to tap into the full potential of the brain, and with people living longer, there is a lot of research going into developing drugs that can protect the brain from degenerative damage. Cognitive problems are usually associated with a deficiency of one or more of the brain chemicals called neurotransmitters.

For example, depression can be caused by low levels of serotonin and dopamine. Whether cognitive defect is caused by accidental brain damage, a genetic condition or ageing, there is a need to look into substances that can potentially reduce or prevent cognitive decline. Diseases like Alzheimer’s disease and dementia don’t have to be inevitable.

Each nootropic affects the brain in a different way, so it is not yet fully understood what the exact mechanisms of action are when someone takes a nootropic. What is understood however, is that:

Nootropics can activate cholinergic networks to increase acetylcholine levels in the brain. Acetylcholine is an important neurotransmitter that plays a role in learning, memory, muscle coordination and movement.

They can increase brain metabolism by stimulating blood circulation so there is more oxygen and energy available to brain neurons. This can boost concentration and focus.

They improve protein synthesis.

They can strengthen the brain’s neural connections, so the brain’s parts will communicate better with each other.
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